A cross-validation procedure for general pedigrees and matched odds ratio fitness metric implemented for the multifactor dimensionality reduction pedigree disequilibrium test.

Abstract excerpt

As genetic epidemiology looks beyond mapping single disease susceptibility loci, interest in detecting epistatic interactions between genes has grown. The dimensionality and comparisons required to search the epistatic space and the inference for a significant result pose challenges for testing epistatic disease models. The multifactor dimensionality reduction-pedigree disequilibrium test (MDR-PDT) was developed...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Algorithms
• Share to Chromosome Mapping