Article
Pedigree tests of transmission disequilibrium.
European journal of human genetics : EJHG - 1 Jul 2000
Abecasis G R, Cookson W O, Cardon L R
Abstract excerpt
High-resolution mapping is essential for the positional cloning of complex disease genes. In outbred populations, linkage disequilibrium is expected to extend for short distances and could provide a powerful fine-mapping tool. Current family-based association tests use nuclear family members to define allelic transmission and controls, but ignore other types of relatives. Here we construct a general approach for...
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