Article
An evaluation of power and type I error of single-nucleotide polymorphism transmission/disequilibrium-based statistical methods under different family structures, missing parental data, and population stratification.
American journal of human genetics - 1 Jan 2007
Nicodemus Kristin K, Luna Augustin, Shugart Yin Yao
Abstract excerpt
Researchers conducting family-based association studies have a wide variety of transmission/disequilibrium (TD)-based methods to choose from, but few guidelines exist in the selection of a particular method to apply to available data. Using a simulation study design, we compared the power and typ...
Topics
- Computer Simulation
- Genotype
- Humans
- Linkage Disequilibrium
- Models, Genetic
- Parents
- Polymorphism, Single Nucleotide
- Population Groups
- Software
- Statistics as Topic