Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Drosophila ARF6-GEF Schizo controls commissure formation by regulating Slit.

Development (Cambridge, England) - 1 Jun 2004

Onel Susanne, Bolke Liane, Klämbt Christian

Abstract excerpt

The CNS of bilateral symmetric organisms is characterized by intensive contralateral axonal connections. Genetic screens in Drosophila have identified only a few genes required for guiding commissural growth cones toward and across the midline. Two evolutionarily conserved signaling molecules, Netrin and Slit, are expressed in the CNS midline cells. Netrin acts primarily as an attractive signaling cue, whereas...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADP-Ribosylation Factor 6
Share to ADP-Ribosylation Factors
Share to Blood Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Central Nervous System

Share to Dynamins

Share to Guanine Nucleotide Exchange Factors

Share to Nerve Growth Factors

Share to Netrin-1

Source

Identifiers

PMID: 15148300
DOI: 10.1242/dev.01147

Genes

ARF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Drosophila ARF6-GEF Schizo controls commissure formation by regulating Slit.PMID 15148300Read ↗

Flamingo, a seven-pass transmembrane cadherin, cooperates with Netrin/Frazzled in Drosophila midline guidance.Semantic proximity Read ↗

Dosage-sensitive and complementary functions of roundabout and commissureless control axon crossing of the CNS midline.Semantic proximity Read ↗

split ends encodes large nuclear proteins that regulate neuronal cell fate and axon extension in the Drosophila embryo.Semantic proximity Read ↗

Mutations affecting growth cone guidance in Drosophila: genes necessary for guidance toward or away from the midline.Semantic proximity Read ↗

Protocadherin Celsr3 is crucial in axonal tract development.Semantic proximity Read ↗

Serrano (sano) functions with the planar cell polarity genes to control tracheal tube length.Semantic proximity Read ↗

Commissureless is required both in commissural neurones and midline cells for axon guidance across the midline.Semantic proximity Read ↗

Dscam guides embryonic axons by Netrin-dependent and -independent functions.Semantic proximity Read ↗

Slit signaling promotes the terminal asymmetric division of neural precursor cells in the Drosophila CNS.Semantic proximity Read ↗

The Abelson tyrosine kinase, the Trio GEF and Enabled interact with the Netrin receptor Frazzled in Drosophila.Semantic proximity Read ↗

The conserved immunoglobulin superfamily member SAX-3/Robo directs multiple aspects of axon guidance in C. elegans.Semantic proximity Read ↗

split ends, a new component of the Drosophila EGF receptor pathway, regulates development of midline glial cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.