Article
Serrano (sano) functions with the planar cell polarity genes to control tracheal tube length.
PLoS genetics - 1 Nov 2009
Chung SeYeon, Vining Melissa S, Bradley Pamela L, Chan Chih-Chiang, Wharton Keith A, Andrew Deborah J
Abstract excerpt
Epithelial tubes are the functional units of many organs, and proper tube geometry is crucial for organ function. Here, we characterize serrano (sano), a novel cytoplasmic protein that is apically enriched in several tube-forming epithelia in Drosophila, including the tracheal system. Loss of sano results in elongated tracheae, whereas Sano overexpression causes shortened tracheae with reduced apical boundaries....
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- Carrier Proteins
- Cell Polarity
- Cytoplasm
- Dishevelled Proteins
- Drosophila Proteins
- Drosophila melanogaster
- Embryo, Nonmammalian
- Epithelium
- Gene Expression
- Phenotype
- Phosphoproteins
- Protein Binding