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Article

Dscam guides embryonic axons by Netrin-dependent and -independent functions.

Development (Cambridge, England) - 1 Dec 2008

Andrews Gracie L, Tanglao Shawna, Farmer W Todd, Morin Steves, Brotman Steven, Berberoglu Michael A, Price Hilary, Fernandez George C, Mastick Grant S, Charron Frédéric, Kidd Thomas

Abstract excerpt

Developing axons are attracted to the CNS midline by Netrin proteins and other as yet unidentified signals. Netrin signals are transduced in part by Frazzled (Fra)/DCC receptors. Genetic analysis in Drosophila indicates that additional unidentified receptors are needed to mediate the attractive response to Netrin. Analysis of Bolwig's nerve reveals that Netrin mutants have a similar phenotype to Down Syndrome...

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Source

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Identifiers

PMID: 18948420
DOI: 10.1242/dev.023739
PMCID: PMC2712571

Genes

DCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dscam guides embryonic axons by Netrin-dependent and -independent functions.PMID 18948420Read ↗

Independent functions of Slit-Robo repulsion and Netrin-Frazzled attraction regulate axon crossing at the midline in Drosophila.Semantic proximity Read ↗

Guidance cues at the Drosophila CNS midline: identification and characterization of two Drosophila Netrin/UNC-6 homologs.Semantic proximity Read ↗

Mushroom body defect is required in parallel to Netrin for midline axon guidance in Drosophila.Semantic proximity Read ↗

A frazzled/DCC-dependent transcriptional switch regulates midline axon guidance.Semantic proximity Read ↗

Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity.Semantic proximity Read ↗

Restoring DSCAM expression rescues neuronal morphology and axon guidance deficits in Down syndromeSemantic proximity Read ↗

Flamingo, a seven-pass transmembrane cadherin, cooperates with Netrin/Frazzled in Drosophila midline guidance.Semantic proximity Read ↗

Genetic analysis of Netrin genes in Drosophila: Netrins guide CNS commissural axons and peripheral motor axons.Semantic proximity Read ↗

Cell autonomy of DSCAM function in retinal development.Semantic proximity Read ↗

A novel mouse Dscam mutation inhibits localization and shedding of DSCAM.Semantic proximity Read ↗

Axon guidance at the midline choice point.Semantic proximity Read ↗

Dscam1 Forms a Complex with Robo1 and the N-Terminal Fragment of Slit to Promote the Growth of Longitudinal Axons.Semantic proximity Read ↗

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