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Article

split ends, a new component of the Drosophila EGF receptor pathway, regulates development of midline glial cells.

Current biology : CB - 1 Jan 2000

Chen F, Rebay I

Abstract excerpt

Signaling by DER, the Drosophila epidermal growth factor receptor tyrosine kinase (RTK), is essential for proper migration and survival of midline glial cells (MGCs) in the embryonic central nervous system (CNS) [1-4]. We recently isolated a gene called split ends (spen) in a screen designed to identify new components of the RTK/Ras pathway [5]. Drosophila Spen and its orthologs are characterized by a distinct...

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Identifiers

PMID: 10959845
DOI: 10.1016/s0960-9822(00)00625-4

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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