Article
Dosage-sensitive and complementary functions of roundabout and commissureless control axon crossing of the CNS midline.
Neuron - 1 Jan 1998
Kidd T, Russell C, Goodman C S, Tear G
Abstract excerpt
commissureless and roundabout lead to complementary mutant phenotypes in which either too few or too many axons cross the midline. The robo;comm double-mutant phenotype is identical to robo alone, suggesting that in the absence of robo, comm is no longer required. Comm is expressed on midline cells; Robo is expressed in a dynamic fashion on growth cones and appears to function as an axon guidance receptor. robo...
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