Commissureless is required both in commissural neurones and midline cells for axon guidance across the midline.

Abstract excerpt

In the absence of Commissureless (Comm) function, axons are unable to extend across the central nervous system midline. Comm downregulates levels of Roundabout (Robo), a receptor for the midline repellent Slit, in order to allow axons to cross the midline. comm transcript is expressed at high levels in the midline glia and Comm protein accumulates on axons at the midline. This has led to the hypothesis that Comm...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Axons
• Share to Central Nervous System
• Share to Embryo, Nonmammalian