Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

split ends encodes large nuclear proteins that regulate neuronal cell fate and axon extension in the Drosophila embryo.

Development (Cambridge, England) - 1 Apr 2000

Kuang B, Wu S C, Shin Y, Luo L, Kolodziej P

Abstract excerpt

split ends (spen) encodes nuclear 600 kDa proteins that contain RNA recognition motifs and a conserved C-terminal sequence. These features define a new protein family, Spen, which includes the vertebrate MINT transcriptional regulator. Zygotic spen mutants affect the growth and guidance of a subset of axons in the Drosophila embryo. Removing maternal and zygotic protein elicits cell-fate and more general...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Axons
Share to Conserved Sequence
Share to Drosophila

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drosophila Proteins

Share to Homeodomain Proteins

Share to Insect Proteins

Share to RNA-Binding Proteins

Share to Stem Cells

Source

Identifiers

PMID: 10704397
DOI: 10.1242/dev.127.7.1517

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

split ends encodes large nuclear proteins that regulate neuronal cell fate and axon extension in the Drosophila embryo.PMID 10704397Read ↗

The product of the split ends gene is required for the maintenance of positional information during Drosophila development.Semantic proximity Read ↗

split ends, a new component of the Drosophila EGF receptor pathway, regulates development of midline glial cells.Semantic proximity Read ↗

spen encodes an RNP motif protein that interacts with Hox pathways to repress the development of head-like sclerites in the Drosophila trunk.Semantic proximity Read ↗

Shootin-1 is required for nervous system development in zebrafish.Semantic proximity Read ↗

Splits ends is a tissue/promoter specific regulator of Wingless signaling.Semantic proximity Read ↗

Genetic control of dorsoventral patterning and neuroblast specification in the Drosophila Central Nervous System.Semantic proximity Read ↗

Identifying targets of the Sox domain protein Dichaete in the Drosophila CNS via targeted expression of dominant negative proteins.Semantic proximity Read ↗

Mouse ACF7 and drosophila short stop modulate filopodia formation and microtubule organisation during neuronal growth.Semantic proximity Read ↗

strawberry notch encodes a conserved nuclear protein that functions downstream of Notch and regulates gene expression along the developing wing margin of Drosophila.Semantic proximity Read ↗

A chimeric enhancer-of-split transcriptional activator drives neural development and achaete-scute expression.Semantic proximity Read ↗

The Drosophila ARF6-GEF Schizo controls commissure formation by regulating Slit.Semantic proximity Read ↗

sidestep encodes a target-derived attractant essential for motor axon guidance in Drosophila.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.