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Article

The Abelson tyrosine kinase, the Trio GEF and Enabled interact with the Netrin receptor Frazzled in Drosophila.

Development (Cambridge, England) - 1 Apr 2005

Forsthoefel David J, Liebl Eric C, Kolodziej Peter A, Seeger Mark A

Abstract excerpt

The attractive Netrin receptor Frazzled (Fra), and the signaling molecules Abelson tyrosine kinase (Abl), the guanine nucleotide-exchange factor Trio, and the Abl substrate Enabled (Ena), all regulate axon pathfinding at the Drosophila embryonic CNS midline. We detect genetic and/or physical interactions between Fra and these effector molecules that suggest that they act in concert to guide axons across the...

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Identifiers

PMID: 15790972
DOI: 10.1242/dev.01736

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Abelson tyrosine kinase, the Trio GEF and Enabled interact with the Netrin receptor Frazzled in Drosophila.PMID 15790972Read ↗

Dosage-sensitive, reciprocal genetic interactions between the Abl tyrosine kinase and the putative GEF trio reveal trio's role in axon pathfinding.Semantic proximity Read ↗

In the absence of frazzled over-expression of Abelson tyrosine kinase disrupts commissure formation and causes axons to leave the embryonic CNS.Semantic proximity Read ↗

The Abl pathway bifurcates to balance Enabled and Rac signaling in axon patterning in Drosophila.Semantic proximity Read ↗

Disabled is a bona fide component of the Abl signaling network.Semantic proximity Read ↗

A frazzled/DCC-dependent transcriptional switch regulates midline axon guidance.Semantic proximity Read ↗

Flamingo, a seven-pass transmembrane cadherin, cooperates with Netrin/Frazzled in Drosophila midline guidance.Semantic proximity Read ↗

Shared receptors in axon guidance: SAX-3/Robo signals via UNC-34/Enabled and a Netrin-independent UNC-40/DCC function.Semantic proximity Read ↗

Independent functions of Slit-Robo repulsion and Netrin-Frazzled attraction regulate axon crossing at the midline in Drosophila.Semantic proximity Read ↗

Genetic analysis of attractin homologs.Semantic proximity Read ↗

Cytoplasmic domain requirements for Frazzled-mediated attractive axon turning at the Drosophila midline.Semantic proximity Read ↗

Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor.Semantic proximity Read ↗

Control of dendritic morphogenesis by Trio in Drosophila melanogaster.Semantic proximity Read ↗

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