Article
Protocadherin Celsr3 is crucial in axonal tract development.
Nature neuroscience - 1 Apr 2005
Tissir Fadel, Bar Isabelle, Jossin Yves, De Backer Olivier, Goffinet Andre M
Abstract excerpt
In the embryonic CNS, the development of axonal tracts is required for the formation of connections and is regulated by multiple genetic and microenvironmental factors. Here we show that mice with inactivation of Celsr3, an ortholog of Drosophila melanogaster flamingo (fmi; also known as starry night, stan) that encodes a seven-pass protocadherin, have marked, selective anomalies of several major axonal...
Topics
- Animals
- Axons
- Body Patterning
- Brain
- Cadherins
- Carbocyanines
- Cloning, Molecular
- Diaphragm
- Frizzled Receptors
- Gene Expression Regulation, Developmental
- Immunohistochemistry