Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Slit signaling promotes the terminal asymmetric division of neural precursor cells in the Drosophila CNS.

Development (Cambridge, England) - 1 Aug 2001

Mehta B, Bhat K M

Abstract excerpt

The bipotential Ganglion Mother Cells, or GMCs, in the Drosophila CNS asymmetrically divide to generate two distinct post-mitotic neurons. Here, we show that the midline repellent Slit (Sli), via its receptor Roundabout (Robo), promotes the terminal asymmetric division of GMCs. In GMC-1 of the RP2/sib lineage, Slit promotes asymmetric division by down regulating two POU proteins, Nubbin and Mitimere. The down...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Nucleus
Share to Central Nervous System
Share to Down-Regulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drosophila

Share to Homeodomain Proteins

Share to POU Domain Factors

Share to Receptors, Immunologic

Share to Roundabout Proteins

Source

Identifiers

PMID: 11688564
DOI: 10.1242/dev.128.16.3161

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Slit signaling promotes the terminal asymmetric division of neural precursor cells in the Drosophila CNS.PMID 11688564Read ↗

Miranda directs Prospero to a daughter cell during Drosophila asymmetric divisions.Semantic proximity Read ↗

Jumeaux, a novel Drosophila winged-helix family protein, is required for generating asymmetric sibling neuronal cell fates.Semantic proximity Read ↗

Slit-Robo signalling prevents sensory cells from crossing the midline in Drosophila.Semantic proximity Read ↗

Binary sibling neuronal cell fate decisions in the Drosophila embryonic central nervous system are nonstochastic and require inscuteable-mediated asymmetry of ganglion mother cells.Semantic proximity Read ↗

Ancestry-independent fate specification and plasticity in the developmental timing of a typical Drosophila neuronal lineage.Semantic proximity Read ↗

The Drosophila Hem/Kette/Nap1 protein regulates asymmetric division of neural precursor cells by regulating localization of Inscuteable and Numb.Semantic proximity Read ↗

Upregulation of Mitimere and Nubbin acts through cyclin E to confer self-renewing asymmetric division potential to neural precursor cells.Semantic proximity Read ↗

Slit/Robo signaling modulates the proliferation of central nervous system progenitors.Semantic proximity Read ↗

Cell division genes promote asymmetric interaction between Numb and Notch in the Drosophila CNS.Semantic proximity Read ↗

A mosaic genetic screen for novel mutations affecting Drosophila neuroblast divisions.Semantic proximity Read ↗

Identification of Miranda protein domains regulating asymmetric cortical localization, cargo binding, and cortical release.Semantic proximity Read ↗

Negative-feedback regulation of proneural proteins controls the timing of neural precursor division.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.