Article
Flamingo, a seven-pass transmembrane cadherin, cooperates with Netrin/Frazzled in Drosophila midline guidance.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Jan 2015
Organisti Cristina, Hein Irina, Grunwald Kadow Ilona C, Suzuki Takashi
Abstract excerpt
During central nervous system development, several guidance cues and receptors, as well as cell adhesion molecules, are required for guiding axons across the midline and along the anterior-posterior axis. In Drosophila, commissural axons sense the midline attractants Netrin A and B (Net) through Frazzled (Fra) receptors. Despite their importance, lack of Net or fra affects only some commissures, suggesting that...
Topics
- Animals
- Axons
- Cadherins
- Cell Adhesion
- Cell Communication
- Central Nervous System
- Drosophila
- Drosophila Proteins
- Mutation
- Nerve Growth Factors
- Nerve Tissue Proteins