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Article

Multiple functions for the invariant AGC triad of U6 snRNA.

RNA (New York, N.Y.) - 1 Jun 2004

Hilliker Angela K, Staley Jonathan P

Abstract excerpt

The invariant AGC triad of U6 snRNA plays an essential, unknown role in splicing. The triad has been implicated in base-pairing with residues in U2, U4, and U6. Through a genetic analysis in S. cerevisiae, we found that most AGC mutants are suppressed both by restoring pairing with U2, supporting the significance of U2/U6 helix Ib, and by destabilizing U2 stem I, indicating that this stem regulates helix Ib...

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Identifiers

PMID: 15146076
DOI: 10.1261/rna.7310704
PMCID: PMC1370584

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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