Mutations in U6 snRNA that alter splice site specificity: implications for the active site.

doi:10.1126/science.8266093

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Mutations in U6 snRNA that alter splice site specificity: implications for the active site.

Science (New York, N.Y.) - 24 Dec 1993

Lesser C F, Guthrie C

Abstract excerpt

What determines the precise sites of cleavage in the two transesterification reactions of messenger RNA (mRNA) splicing is a major unsolved question. Mutation of the invariant G (guanosine) at position 5 of 5' splice sites in Saccharomyces cerevisiae introns activates cleavage at nearby aberrant sites. A genetic approach was used to test the hypothesis that a base-pairing interaction between the 5' splice site...

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Mutations in U6 snRNA that alter splice site specificity: implications for the active site.

Abstract excerpt

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Mutations in U6 snRNA that alter splice site specificity: implications for the active site.

Abstract excerpt

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