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Article

Functionally redundant interactions between U2 and U6 spliceosomal snRNAs.

Genes & development - 15 Feb 1996

Field D J, Friesen J D

Abstract excerpt

Base-pairing between U2 and U6 snRNAs to form intermolecular helix II has been demonstrated previously as a requirement for pre-mRNA splicing in mammalian cells. In contrast, deletion and substitution mutation experiments in yeast have indicated that helix II is not essential; instead, other regions of U2 and U6 have been proposed to pair, forming a helix called Ib. To investigate the importance of U2/U6 helices...

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Identifiers

PMID: 8600031
DOI: 10.1101/gad.10.4.489

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functionally redundant interactions between U2 and U6 spliceosomal snRNAs.PMID 8600031Read ↗

The conserved central domain of yeast U6 snRNA: importance of U2-U6 helix Ia in spliceosome assembly.Semantic proximity Read ↗

Invariant U2 RNA sequences bordering the branchpoint recognition region are essential for interaction with yeast SF3a and SF3b subunits.Semantic proximity Read ↗

Multiple functions for the invariant AGC triad of U6 snRNA.Semantic proximity Read ↗

Multiple roles for U6 snRNA in the splicing pathway.Semantic proximity Read ↗

Mutation in the U2 snRNA influences exon interactions of U5 snRNA loop 1 during pre-mRNA splicing.Semantic proximity Read ↗

In vitro reconstitution of yeast splicing with U4 snRNA reveals multiple roles for the 3' stem-loop.Semantic proximity Read ↗

Rearrangement of competing U2 RNA helices within the spliceosome promotes multiple steps in splicing.Semantic proximity Read ↗

Spliceosome assembly in the absence of stable U4/U6 RNA pairing.Semantic proximity Read ↗

Functionally important structural elements of U12 snRNA.Semantic proximity Read ↗

Brr2p-mediated unwinding of U4/U6 is promoted by a mutually exclusive intra-molecular stem loop in U4 and involves destabilization of the 5’ stem-loop of U4Semantic proximity Read ↗

Lethal and temperature-sensitive mutations and their suppressors identify an essential structural element in U2 small nuclear RNA.Semantic proximity Read ↗

Sequences upstream of the branch site are required to form helix II between U2 and U6 snRNA in a trans-splicing reaction.Semantic proximity Read ↗

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