Multiple roles for U6 snRNA in the splicing pathway.

doi:10.1101/gad.4.12b.2264

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Article

Multiple roles for U6 snRNA in the splicing pathway.

Genes & development - 1 Dec 1990

Madhani H D, Bordonné R, Guthrie C

Abstract excerpt

U6 is the most highly conserved of the five spliceosomal RNAs. It is associated with U4 by an extensive base-pairing interaction, which is disrupted immediately prior to the first nucleolytic step of splicing. It has been proposed that this event activates catalysis by unmasking U6. Using a combi...

Topics

Base Sequence
Blotting, Northern
Gene Library
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutation
Nucleic Acid Conformation
Phenotype
RNA Splicing
RNA, Fungal
RNA, Small Nuclear
Ribonucleoproteins
Ribonucleoproteins, Small Nuclear
Saccharomyces cerevisiae

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