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Article

Multiple roles for U6 snRNA in the splicing pathway.

Genes & development - 1 Dec 1990

Madhani H D, Bordonné R, Guthrie C

Abstract excerpt

U6 is the most highly conserved of the five spliceosomal RNAs. It is associated with U4 by an extensive base-pairing interaction, which is disrupted immediately prior to the first nucleolytic step of splicing. It has been proposed that this event activates catalysis by unmasking U6. Using a combination of doped synthesis and site-directed mutagenesis to generate point mutations in U6, we have now identified 12...

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Identifiers

PMID: 2149118
DOI: 10.1101/gad.4.12b.2264

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Click a neighbor to travelStep 1 · 12 closest

Multiple roles for U6 snRNA in the splicing pathway.PMID 2149118Read ↗

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Discrete domains of human U6 snRNA required for the assembly of U4/U6 snRNP and splicing complexes.Semantic proximity Read ↗

The conserved central domain of yeast U6 snRNA: importance of U2-U6 helix Ia in spliceosome assembly.Semantic proximity Read ↗

Suppressors of a U4 snRNA mutation define a novel U6 snRNP protein with RNA-binding motifs.Semantic proximity Read ↗

In vitro reconstitution of yeast splicing with U4 snRNA reveals multiple roles for the 3' stem-loop.Semantic proximity Read ↗

Multiple functions for the invariant AGC triad of U6 snRNA.Semantic proximity Read ↗

Functionally redundant interactions between U2 and U6 spliceosomal snRNAs.Semantic proximity Read ↗

Structural and mechanistic basis for preferential deadenylation of U6 snRNA by Usb1.Semantic proximity Read ↗

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