Article
Functionally important structural elements of U12 snRNA.
Nucleic acids research - 1 Oct 2011
Sikand Kavleen, Shukla Girish C
Abstract excerpt
U12 snRNA is analogous to U2 snRNA of the U2-dependent spliceosome and is essential for the splicing of U12-dependent introns in metazoan cells. The essential region of U12 snRNA, which base pairs to the branch site of minor class introns is well characterized. However, other regions which are outside of the branch site base pairing region are not yet characterized and the requirement of these structures in...
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