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Article

A dynamic bulge in the U6 RNA internal stem-loop functions in spliceosome assembly and activation.

RNA (New York, N.Y.) - 1 Dec 2007

McManus C Joel, Schwartz Matthew L, Butcher Samuel E, Brow David A

Abstract excerpt

The highly conserved internal stem-loop (ISL) of U6 spliceosomal RNA is unwound for U4/U6 complex formation during spliceosome assembly and reformed upon U4 release during spliceosome activation. The U6 ISL is structurally similar to Domain 5 of group II self-splicing introns, and contains a dynamic bulge that coordinates a Mg++ ion essential for the first catalytic step of splicing. We have analyzed the causes...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17925343
DOI: 10.1261/rna.699907
PMCID: PMC2080595

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Source receipt: pubmed, retrieved 7 Sept 2026.

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A dynamic bulge in the U6 RNA internal stem-loop functions in spliceosome assembly and activation.PMID 17925343Read ↗

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