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Article

Invariant U2 RNA sequences bordering the branchpoint recognition region are essential for interaction with yeast SF3a and SF3b subunits.

Molecular and cellular biology - 1 Mar 1996

Yan D, Ares M

Abstract excerpt

U2 small nuclear RNA (snRNA) contains a sequence (GUAGUA) that pairs with the intron branchpoint during splicing. This sequence is contained within a longer invariant sequence of unknown secondary structure and function that extends between U2 and I and stem IIa. A part of this region has been proposed to pair with U6 in a structure called helix III. We made mutations to test the function of these nucleotides in...

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Identifiers

PMID: 8622683
DOI: 10.1128/MCB.16.3.818
PMCID: PMC231062

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Invariant U2 RNA sequences bordering the branchpoint recognition region are essential for interaction with yeast SF3a and SF3b subunits.PMID 8622683Read ↗

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Lethal and temperature-sensitive mutations and their suppressors identify an essential structural element in U2 small nuclear RNA.Semantic proximity Read ↗

Invariant U2 snRNA nucleotides form a stem loop to recognize the intron early in splicing.Semantic proximity Read ↗

Identification of a U2/U6 helix la mutant that influences 3' splice site selection during nuclear pre-mRNA splicing.Semantic proximity Read ↗

Mutations at the 3' splice site can be suppressed by compensatory base changes in U1 snRNA in fission yeast.Semantic proximity Read ↗

Functionally redundant interactions between U2 and U6 spliceosomal snRNAs.Semantic proximity Read ↗

Structure-function analysis of the 5' end of yeast U1 snRNA highlights genetic interactions with the Msl5*Mud2 branchpoint-binding complex and other spliceosome assembly factors.Semantic proximity Read ↗

Mutations in U6 snRNA that alter splice site specificity: implications for the active site.Semantic proximity Read ↗

Rearrangement of competing U2 RNA helices within the spliceosome promotes multiple steps in splicing.Semantic proximity Read ↗

Limited functional equivalence of phylogenetic variation in small nuclear RNA: yeast U2 RNA with altered branchpoint complementarity inhibits splicing and produces a dominant lethal phenotype.Semantic proximity Read ↗

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