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Article

Wild-type is the optimal sequence of the HDV ribozyme under cotranscriptional conditions.

RNA (New York, N.Y.) - 1 Dec 2007

Chadalavada Durga M, Cerrone-Szakal Andrea L, Bevilacqua Philip C

Abstract excerpt

RNA viruses are responsible for a variety of human diseases, and the pathogenicity of RNA viruses is often attributed to a high rate of mutation. Self-cleavage activity of the wild-type hepatitis delta virus (HDV) ribozyme as measured in standard divalent ion renaturation assays is biphasic and mostly slow and can be improved by multiple rational changes to ribozyme sequence or by addition of chemical...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 17956974
DOI: 10.1261/rna.778107
PMCID: PMC2080589

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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