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Article

General acid catalysis by the hepatitis delta virus ribozyme.

Nature chemical biology - 1 Jun 2005

Das Subha R, Piccirilli Joseph A

Abstract excerpt

Recent crystallographic and functional analyses of RNA enzymes have raised the possibility that the purine and pyrimidine nucleobases may function as general acid-base catalysts. However, this mode of nucleobase-mediated catalysis has been difficult to establish unambiguously. Here, we used a hyp...

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Identifiers

PMID: 16407993
DOI: 10.1038/nchembio703

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16407993-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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