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Article

Role of an active site adenine in hairpin ribozyme catalysis.

Journal of molecular biology - 24 Jun 2005

Kuzmin Yaroslav I, Da Costa Carla P, Cottrell Joseph W, Fedor Martha J

Abstract excerpt

The hairpin ribozyme is a small catalytic RNA that accelerates reversible cleavage of a phosphodiester bond. Structural and mechanistic studies suggest that divalent metals stabilize the functional structure but do not participate directly in catalysis. Instead, two active site nucleobases, G8 an...

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Source

Identifiers

PMID: 15907933
DOI: 10.1016/j.jmb.2005.04.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15907933-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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