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Article

Identification of the catalytic Mg²⁺ ion in the hepatitis delta virus ribozyme.

Biochemistry - 22 Jan 2013

Chen Ji, Ganguly Abir, Miswan Zulaika, Hammes-Schiffer Sharon, Bevilacqua Philip C, Golden Barbara L

Abstract excerpt

The hepatitis delta virus ribozyme catalyzes an RNA cleavage reaction using a catalytic nucleobase and a divalent metal ion. The catalytic base, C75, serves as a general acid and has a pK(a) shifted toward neutrality. Less is known about the role of metal ions in the mechanism. A recent crystal structure of the precleavage ribozyme identified a Mg²⁺ ion that interacts through its partial hydration sphere with the...

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Identifiers

PMID: 23311293
DOI: 10.1021/bi3013092
PMCID: PMC3558840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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