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Article

Mapping the BKCa channel's "Ca2+ bowl": side-chains essential for Ca2+ sensing.

The Journal of general physiology - 1 May 2004

Bao Lin, Kaldany Christina, Holmstrand Ericka C, Cox Daniel H

Abstract excerpt

There is controversy over whether Ca(2+) binds to the BK(Ca) channel's intracellular domain or its integral-membrane domain and over whether or not mutations that reduce the channel's Ca(2+) sensitivity act at the point of Ca(2+) coordination. One region in the intracellular domain that has been implicated in Ca(2+) sensing is the "Ca(2+) bowl". This region contains many acidic residues, and large Ca(2+)-bowl...

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Source

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Identifiers

PMID: 15111643
DOI: 10.1085/jgp.200409052
PMCID: PMC2234491

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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