Article

Coupling of Ca <sup>2+</sup> and voltage activation in BK channels through the αB helix/voltage sensor interface

2020-01-31

Abstract excerpt

Large conductance Ca 2+ and voltage activated K + (BK) channels control membrane excitability in many cell types. BK channels are tetrameric. Each subunit is comprised of a voltage sensor domain (VSD), a central pore gate domain, and a large cytoplasmic domain (CTD) that contains the Ca 2+ sensors. While it is known that BK channels are activated by voltage and Ca 2+ , and that voltage and Ca 2+ activations i...

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Literature Corpus work: 89d0795b-0c17-543d-bba8-36f87e03b2c8
DOI: 10.1101/2020.01.29.925545

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