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Article

Calcium activation of BK(Ca) potassium channels lacking the calcium bowl and RCK domains.

Nature - 5 Dec 2002

Piskorowski Rebecca, Aldrich Richard W

Abstract excerpt

In many physiological systems such as neurotransmitter release, smooth muscle relaxation and frequency tuning of auditory hair cells, large-conductance calcium-activated potassium (BK(Ca)) channels create a connection between calcium signalling pathways and membrane excitability. BK(Ca) channels are activated by voltage and by micromolar concentrations of intracellular calcium. Although it is possible to open...

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Identifiers

PMID: 12466841
DOI: 10.1038/nature01199

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Calcium activation of BK(Ca) potassium channels lacking the calcium bowl and RCK domains.PMID 12466841Read ↗

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Homology modeling identifies C-terminal residues that contribute to the Ca2+ sensitivity of a BKCa channel.Semantic proximity Read ↗

Functional validation of Ca2+-binding residues from the crystal structure of the BK ion channel.Semantic proximity Read ↗

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