Article
Elimination of the BK(Ca) channel's high-affinity Ca(2+) sensitivity.
The Journal of general physiology - 1 Aug 2002
Bao Lin, Rapin Anne M, Holmstrand Ericka C, Cox Daniel H
Abstract excerpt
We report here a combination of site-directed mutations that eliminate the high-affinity Ca(2+) response of the large-conductance Ca(2+)-activated K(+) channel (BK(Ca)), leaving only a low-affinity response blocked by high concentrations of Mg(2+). Mutations at two sites are required, the "Ca(2+) bowl," which has been implicated previously in Ca(2+) binding, and M513, at the end of the channel's seventh...
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