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Article

Divalent cation sensitivity of BK channel activation supports the existence of three distinct binding sites.

The Journal of general physiology - 1 Mar 2005

Zeng Xu-Hui, Xia Xiao-Ming, Lingle Christopher J

Abstract excerpt

Mutational analyses have suggested that BK channels are regulated by three distinct divalent cation-dependent regulatory mechanisms arising from the cytosolic COOH terminus of the pore-forming alpha subunit. Two mechanisms account for physiological regulation of BK channels by microM Ca2+. The third may mediate physiological regulation by mM Mg2+. Mutation of five aspartate residues (5D5N) within the so-called...

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Identifiers

PMID: 15738049
DOI: 10.1085/jgp.200409239
PMCID: PMC2234011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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