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Article

Multiple regulatory sites in large-conductance calcium-activated potassium channels.

Nature - 22 Aug 2002

Xia Xiao-Ming, Zeng Xuhui, Lingle Christopher J

Abstract excerpt

Large conductance, Ca(2+)- and voltage-activated K(+) channels (BK) respond to two distinct physiological signals -- membrane voltage and cytosolic Ca(2+) (refs 1, 2). Channel opening is regulated by changes in Ca(2+) concentration spanning 0.5 micro M to 50 mM (refs 2-5), a range of Ca(2+) sensitivity unusual among Ca(2+)-regulated proteins. Although voltage regulation arises from mechanisms shared with other...

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Identifiers

PMID: 12192411
DOI: 10.1038/nature00956

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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