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Article

A regulatory calcium-binding site at the subunit interface of CLC-K kidney chloride channels.

The Journal of general physiology - 1 Sept 2010

Gradogna Antonella, Babini Elena, Picollo Alessandra, Pusch Michael

Abstract excerpt

The two human CLC Cl(-) channels, ClC-Ka and ClC-Kb, are almost exclusively expressed in kidney and inner ear epithelia. Mutations in the genes coding for ClC-Kb and barttin, an essential CLC-K channel beta subunit, lead to Bartter syndrome. We performed a biophysical analysis of the modulatory effect of extracellular Ca(2+) and H(+) on ClC-Ka and ClC-Kb in Xenopus oocytes. Currents increased with increasing...

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Source

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Identifiers

PMID: 20805576
DOI: 10.1085/jgp.201010455
PMCID: PMC2931146

Genes

CLC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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