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Article

Functional validation of Ca2+-binding residues from the crystal structure of the BK ion channel.

Biochimica et biophysica acta. Biomembranes - 1 Apr 2018

Kshatri Aravind S, Gonzalez-Hernandez Alberto J, Giraldez Teresa

Abstract excerpt

BK channels are dually regulated by voltage and Ca2+, providing a cellular mechanism to couple electrical and chemical signalling. Intracellular Ca2+ concentration is sensed by a large cytoplasmic region in the channel known as "gating ring", which is formed by four tandems of regulator of conductance for K+ (RCK1 and RCK2) domains. The recent crystal structure of the full-length BK channel from Aplysia...

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Source

Identifiers

PMID: 28966112
DOI: 10.1016/j.bbamem.2017.09.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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