Article
An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing.
Neuron - 24 Jun 2010
Yang Junqiu, Krishnamoorthy Gayathri, Saxena Akansha, Zhang Guohui, Shi Jingyi, Yang Huanghe, Delaloye Kelli, Sept David, Cui Jianmin
Abstract excerpt
Ca(2+)-activated BK channels modulate neuronal activities, including spike frequency adaptation and synaptic transmission. Previous studies found that Ca(2+)-binding sites and the activation gate are spatially separated in the channel protein, but the mechanism by which Ca(2+) binding opens the gate over this distance remains unknown. By studying an Asp-to-Gly mutation (D434G) associated with human syndrome of...
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