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Article

Computational tools for understanding sequence variability in recombination signals.

Immunological reviews - 1 Aug 2004

Cowell Lindsay G, Davila Marco, Ramsden Dale, Kelsoe Garnett

Abstract excerpt

The recombination signals (RSs) that guide V(D)J rearrangement are remarkably diverse. In mice, fewer than 16% of RSs carry consensus heptamers and nonamers and none also contain a consensus spacer sequence. It is increasingly clear that this variability regulates recombination: genetic variability in RSs may help enforce allelic exclusion, determine the general nature of antigen receptor repertoires, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Rearrangement, B-Lymphocyte

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Source

Identifiers

PMID: 15242396
DOI: 10.1111/j.0105-2896.2004.00171.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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