Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

V(D)J Recombination: Mechanism, Errors, and Fidelity.

Microbiology spectrum - 1 Dec 2014

Roth David B

Abstract excerpt

V(D)J recombination, the mechanism responsible for generating antigen receptor diversity, has the potential to generate aberrant DNA rearrangements in developing lymphocytes. Indeed, the recombinase has been implicated in several different kinds of errors leading to oncogenic transformation. Here we review the basic aspects of V(D)J recombination, mechanisms underlying aberrant DNA rearrangements, and the types...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Variation
Share to Receptors, Antigen
Share to V(D)J Recombination

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to VDJ Recombinases

Source

Open in PubMed Open full text

Identifiers

PMID: 26104458
DOI: 10.1128/microbiolspec.MDNA3-0041-2014
PMCID: PMC5089068

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

V(D)J Recombination: Mechanism, Errors, and Fidelity.PMID 26104458Read ↗

V(D)J Recombination: Molecular Biology and RegulationSemantic proximity Read ↗

Illegitimate V(D)J recombination involving nonantigen receptor loci in lymphoid malignancySemantic proximity Read ↗

Mechanisms that control antigen receptor variable region gene assembly.Semantic proximity Read ↗

Control of antigen receptor diversity through spatial regulation of V(D)J recombination.Semantic proximity Read ↗

Breakpoint sites disclose the role of the V(D)J recombination machinery in the formation of T-cell receptor (TCR) and non-TCR associated aberrations in T-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

Impairment of V(D)J recombination in double-strand break repair mutants.Semantic proximity Read ↗

The Role of DNA Repair in Immunological Diversity: From Molecular Mechanisms to Clinical RamificationsSemantic proximity Read ↗

Gene segment selection in V(D)J recombination: accessibility and beyond.Semantic proximity Read ↗

Non-canonical D1-D2 recombination produces two types of rearrangements and represents a conservative hidden stage of T-cell receptor beta chain generationSemantic proximity Read ↗

DNA damage and repair during lymphoid development: antigen receptor diversity, genomic integrity and lymphomagenesis.Semantic proximity Read ↗

Genetic and epigenetic control of V gene rearrangement frequency.Semantic proximity Read ↗

The evolving contribution of hematopoietic progenitor cells to lymphomagenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.