Mechanisms that control antigen receptor variable region gene assembly.

doi:10.1006/smim.1994.1024

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Article

Mechanisms that control antigen receptor variable region gene assembly.

Seminars in immunology - 1 Jun 1994

Okada A, Alt F W

Abstract excerpt

The somatic assembly of antigen receptor genes--known as V(D)J recombination--is a highly regulated process at several different levels. V(D)J rearrangement is limited to stages of early B and T cell development by the lymphoid specific expression of recombinase activity. A common recombinase is...

Topics

Alleles
Animals
Gene Rearrangement, B-Lymphocyte
Gene Rearrangement, T-Lymphocyte
Humans
Immunoglobulins
Receptors, Antigen
Recombination, Genetic
Transcription, Genetic

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