Article
Mechanisms that control antigen receptor variable region gene assembly.
Seminars in immunology - 1 Jun 1994
Okada A, Alt F W
Abstract excerpt
The somatic assembly of antigen receptor genes--known as V(D)J recombination--is a highly regulated process at several different levels. V(D)J rearrangement is limited to stages of early B and T cell development by the lymphoid specific expression of recombinase activity. A common recombinase is apparently responsible for the rearrangement of all antigen receptor loci. Thus, the tissue specific and ordered...
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