Article
Not all HLA DR3 DQ2 haplotypes confer equal susceptibility to coeliac disease: transmission analysis in families.
Scandinavian journal of gastroenterology - 1 Jan 2002
Karell K, Holopainen P, Mustalahti K, Collin P, Mäki M, Partanen J
Abstract excerpt
BACKGROUND: HLA-DQ is the only established susceptibility factor for coeliac disease. We tested whether all HLA haplotypes with the known risk marker, HLA-DQ2, confer equal susceptibility to coeliac disease, i.e. whether haplotype transmission from DQ2 homozygous parents to patients is random. The random transmission would strengthen the importance of DQ2 as the only risk factor within the HLA region. METHODS:...
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