Article
HLA-DQ genetics in children with celiac disease: a meta-analysis suggesting a two-step genetic screening procedure starting with HLA-DQ β chains.
Pediatric research - 1 Mar 2018
De Silvestri Annalisa, Capittini Cristina, Poddighe Dimitri, Valsecchi Chiara, Marseglia Gianluigi, Tagliacarne Sara Carlotta, Scotti Valeria, Rebuffi Chiara, Pasi Annamaria, Martinetti Miryam, Tinelli Carmine
Abstract excerpt
BackgroundSpecific HLA-DQ genes have been recognized as necessary - but not sufficient - factors for the occurrence of Celiac Disease (CD). Through a meta-analysis, evaluating the distribution of CD-related HLA genotypes in children, we aimed at providing insights for a potential widened screening strategy.MethodsAfter a systematic search on the association between class II HLA genes and CD in children, 46...
Topics
- Adolescent
- Alleles
- Case-Control Studies
- Celiac Disease
- Child
- Cohort Studies
- Female
- Genetic Testing
- Genotype
- HLA-DQ beta-Chains
- Humans
- Male
- Odds Ratio