Article
HLA related genetic risk for coeliac disease.
Gut - 1 Aug 2007
Bourgey Mathieu, Calcagno Giuseppe, Tinto Nadia, Gennarelli Daniela, Margaritte-Jeannin Patricia, Greco Luigi, Limongelli Maria Giovanna, Esposito Oscar, Marano Caterina, Troncone Riccardo, Spampanato Antonella, Clerget-Darpoux Françoise, Sacchetti Lucia
Abstract excerpt
BACKGROUND: Several studies have shown an elevated prevalence of coeliac disease (CD) in sibs of coeliac patients (risk 8-12%). AIM AND METHOD: We evaluated the risk that sibs of children with CD will also develop CD. This cohort of 188 Italian families was composed of probands with CD, at least one sib and both parents. CD status was determined and human leucocyte antigen (HLA)-DQ genotyping performed in all...
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