Article
Phenotypic variance in childhood coeliac disease and the HLA-DQ/DR dose effect.
Scandinavian journal of gastroenterology - 1 Jan 2009
Vermeulen Beatrijs A N, Hogen Esch Caroline E, Yuksel Zehre, Koning Frits, Verduijn Willem, Doxiadis Ilias I N, Schreuder Geziena M Th, Mearin M Luisa
Abstract excerpt
OBJECTIVE: Coeliac disease (CD) is associated with HLA-DQ2 and DQ8. The clinical picture is variable and certain human leucocyte antigen (HLA) DQ/DR combinations have a higher relative risk (RR) for CD than others. Moreover, the HLA-DQ gene-dose effect has an impact on the strength of the gluten-specific T-cell response and thus may correlate with clinical presentation and severity of CD. The aim of this study...
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