Article
HLA-DQ and risk gradient for celiac disease.
Human immunology - 1 Jan 2009
Megiorni Francesca, Mora Barbara, Bonamico Margherita, Barbato Maria, Nenna Raffaella, Maiella Giulia, Lulli Patrizia, Mazzilli Maria Cristina
Abstract excerpt
Celiac disease (CD) is a rare example of multifactorial disorder in which a genetic test is of great clinical relevance, as the disease rarely develops in the absence of specific HLA alleles. We typed DR-DQ genes in 437 Italian children with celiac disease, 834 first-degree relatives, and 551 controls. Of patients, 91% carried DQ2 and/or DQ8 heterodimers, 6% only had beta2 chain, 2% was alpha5 positive, and four...
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