Article
HLA-DQ relative risks for coeliac disease in European populations: a study of the European Genetics Cluster on Coeliac Disease.
Tissue antigens - 1 Jun 2004
Margaritte-Jeannin P, Babron M C, Bourgey M, Louka A S, Clot F, Percopo S, Coto I, Hugot J P, Ascher H, Sollid L M, Greco L, Clerget-Darpoux F
Abstract excerpt
Coeliac disease is an enteropathy due to an intolerance to gluten. The association between HLA-DQ genes and CD is well established. The majority of patients carry the HLA-DQ heterodimer encoded by DQA1*05/DQB1*02, either in cis or in trans. The remaining patients carry either part of the DQ heterodimer or DQA1*03-DQB1*0302. The aim of the study was to estimate the risks associated with different DQ genotypes in...
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