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Article

K-ras point mutations in human colorectal carcinomas: relation to aneuploidy and metastasis.

International journal of cancer - 19 Aug 1992

Suchy B, Zietz C, Rabes H M

Abstract excerpt

Material from paraffin sections of 109 human colorectal carcinomas, mostly obtained at autopsy, was analyzed for the presence of K-ras point mutations at codon 12, position 2. Mutations at this position were found in 23 cases (21.1%). Aneuploid colorectal carcinomas showed a significantly higher prevalence of K-ras point mutations than diploid tumors, suggesting an involvement of ras mutations in the development...

Topics

Aneuploidy
Base Sequence
Colorectal Neoplasms
Genes, ras
Humans
Molecular Sequence Data
Mutation
Neoplasm Metastasis

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1500224
DOI: 10.1002/ijc.2910520107

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1500224-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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