Article
Association of K-ras mutations with liver metastases from colorectal carcinoma.
Anticancer research - 1 Jan 2000
Tsunoda Akira, Iijima Takeru, Tsunoda Yuko, Nakao Kentaroh, Miyaki Michiko, Kusano Mitsuo
Abstract excerpt
BACKGROUND: Colorectal carcinomas were studied regarding early proof of liver metastases through determination of K-ras mutations. PATIENTS AND METHODS: Seventy-seven colorectal carcinomas were investigated for the presence of point mutations in codon 12 and 13 of the K-ras gene, using single-strand conformation polymorphism (SSCP) analysis and direct sequencing. RESULTS: Twenty-six carcinomas were positive for...
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