K-ras codon 12 mutation induces higher level of resistance to apoptosis and predisposition to anchorage-independent growth than codon 13 mutation or proto-oncogene overexpression.

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Article

K-ras codon 12 mutation induces higher level of resistance to apoptosis and predisposition to anchorage-independent growth than codon 13 mutation or proto-oncogene overexpression.

Cancer research - 1 Dec 2000

Guerrero S, Casanova I, Farré L, Mazo A, Capellà G, Mangues R

Abstract excerpt

The position of the point mutation in the c-K-ras gene appears associated with different degrees of aggressiveness in human colorectal tumors. In addition, colon tumors carrying K-ras codon 12 mutations associate with lower levels of apoptosis than tumors lacking this mutation. To test the hypothesis of a distinct transforming capacity of different K-ras forms in an in vitro system, we generated stable...

Topics

3T3 Cells
Animals
Apoptosis
Cadherins
Cell Adhesion
Cell Communication
Cell Division
Cell Transformation, Neoplastic
Codon
Cytoskeletal Proteins
Enzyme Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Focal Adhesion Kinase 1

Focal Adhesion Protein-Tyrosine Kinases

Gene Expression Regulation, Neoplastic

Genes, ras

MAP Kinase Signaling System

Mice

Phenotype

Source

Open in PubMed

Identifiers

PMID: 11118062

Provenance

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