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Article

Detection of high incidence of K-ras oncogenes during human colon tumorigenesis.

Nature - 1 Jan 2000

Forrester K, Almoguera C, Han K, Grizzle W E, Perucho M

Abstract excerpt

RNAse A mismatch cleavage analysis of 66 primary human colon tumors reveals a high incidence of K-ras genes with mutations at position 12. No apparent correlation was found between the presence of mutant oncogenes and the degree of invasiveness of the tumours but evidence for ras mutational activation in premalignant tissue was obtained.

Topics

Adenocarcinoma
Adenoma
Aged
Aged, 80 and over
Codon
Colonic Neoplasms
Female
Humans
Male
Middle Aged
Mutation
Nucleic Acid Hybridization
Oncogenes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA

RNA, Complementary

Ribonuclease, Pancreatic

Source

Identifiers

PMID: 2438556
DOI: 10.1038/327298a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2438556-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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