Article
Concurrent mutation in exons 1 and 2 of the K-ras oncogene in colorectal cancer.
Folia histochemica et cytobiologica - 1 Jan 2011
Palmirotta Raffaele, Savonarola Annalisa, Ludovici Giorgia, De Marchis Maria Laura, Covello Renato, Ettorre Giuseppe Maria, Ialongo Cristiano, Guadagni Fiorella
Abstract excerpt
The K-ras gene is frequently mutated in colorectal cancer and has been associated with tumor initiation and progression; approximately 90% of the activating mutations are found in codons 12 and 13 of exon 1 and just under 5% in codon 61 located in exon 2. These mutations determine single aminoacidic substitutions in the GTPase pocket leading to a block of the GTP hydrolytic activity of the K-ras p21 protein, and...
Topics
- Base Sequence
- Codon
- Colorectal Neoplasms
- Exons
- Genes, ras
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction