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K-<i>ras</i>Mutations and Prognosis in Large-Bowel Carcinomas

1 Jan 1997

Abstract excerpt

BACKGROUND: Colorectal carcinogenesis is regarded as a multistep process involving several genetic alterations, with mutation in the K-ras gene in about half of the tumours. We aimed at clarifying the role of this genetic alteration related to survival and clinicopathologic variables. METHODS: One hundred large-bowel carcinomas operated on between 1978 and 1982 were studied for the presence of point mutations in...

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PMID: 9018769
DOI: 10.3109/00365529709025065

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