Higher frequency of point mutations in the c-K-ras 2 gene in human colorectal adenomas with severe atypia than in carcinomas.

doi:10.1111/j.1349-7006.1991.tb01836.x

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Article

Higher frequency of point mutations in the c-K-ras 2 gene in human colorectal adenomas with severe atypia than in carcinomas.

Japanese journal of cancer research : Gann - 1 Mar 1991

Ando M, Maruyama M, Oto M, Takemura K, Endo M, Yuasa Y

Abstract excerpt

Human colorectal carcinomas may be induced from adenomas or they may occur de novo. To examine which is the main pathway, we analyzed point mutations at codon 12 in the c-K-ras 2 gene in 73 colorectal carcinomas, 13 metastatic tumors, 72 adenomas and 30 normal tissues. The c-K-ras 2 codon 12 mutation frequency was 0/30 in normal tissues, 0/17 in adenomas with mild atypia, 3/37 (8.1%) in adenomas with moderate...

Topics

Adenoma
Base Sequence
Carcinoma
Codon
Colonic Neoplasms
Deoxyribonuclease HpaII
Deoxyribonucleases, Type II Site-Specific
Genes, ras
Humans
Intestinal Mucosa
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Oligonucleotide Probes

Polymerase Chain Reaction

Polymorphism, Restriction Fragment Length

Rectal Neoplasms

Reference Values

Source

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Identifiers

PMID: 1708754
DOI: 10.1111/j.1349-7006.1991.tb01836.x
PMCID: PMC5918406

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1708754-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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